Continuous Positive Airway Pressure can improve night-time urinary frequency in Parkinson’s disease with sleep apnea.

Uchiyama T1, Yamamoto T2, Sakakibara R3, Murai H4

Research Type

Clinical

Abstract Category

Nocturia

Abstract 276
Nocturia
Scientific Podium Short Oral Session 29
Friday 9th October 2026
15:22 - 15:30
Parallel Hall 2
Nocturia Conservative Treatment Neuropathies: Central
1. International University of Hearth and Welfare School of Medicine Department of Neurology, Chiba, Japan / International University of Hearth and Welfare Shioya Hospital Department of Neurology, Tochigi, Japan / International University of Hearth and Welfare Narita Hospital Department of Neurology, Chiba, Japan / Chiba University School of Medicine Department of Neurology, Chiba, Japan, 2. Chiba prefectural university of health science Department of Rehabilitation, Division of Occupational Therapy, Chiba, Japan / Chiba University School of Medicine Department of Neurology, Chiba, Japan, 3. Neurology Clinic Tsudanuma, Chiba, Japan / Chiba University School of Medicine Department of Neurology, Chiba, Japan, 4. International University of Hearth and Welfare School of Medicine Department of Neurology, Chiba, Japan / International University of Hearth and Welfare Narita Hospital Department of Neurology, Chiba, Japan
Presenter
T

Tomoyuki Uchiyama
International University of Hearth and Welfare School of Medicine Department of Neurology, Chiba, Japan / International University of Hearth and Welfare Shioya Hospital Department of Neurology, Tochigi, Japan / International University of Hearth and Welfare Narita Hospital Department of Neurology, Chiba, Japan / Chiba University School of Medicine Department of Neurology, Chiba, Japan
Links

Abstract

Hypothesis / aims of study 
Continuous Positive Airway Pressure (CPAP) is a non-invasive treatment for obstructive sleep apnea (OSA), reducing snoring, improving sleep quality, and lowering risks for heart disease, stroke, and high blood pressure. In patients with Parkinson disease (PD), nocturia/night-time urinary frequency is common and decrease in Quality of life. And sleep apnea (SA) is also common in patients with PD and is composed of obstructive cause and central cause. Recently, some articles reported that CPAP treatment improves nocturia/night-time urinary frequency in the patients with OSA. In our clinical experience, we have some experiences that CPAP ameliorated nocturia/night-time urinary frequency in PD patients with SA. However, there is no report to evaluate the effect of CPAP on nocturia/night-time urinary frequency in PD patients with SA. We therefore investigate the effect of CPAP on nocturia/night-time urinary frequency in PD patients with SA.
Study design, materials and methods 
Eight PD patients with CPAP treatment for SA were observed. We investigated the number of times to urinate at night and apnea hypopnea index (AHI) before and several months after receiving CPAP treatment.
Results 
Six PD patients were able to do CPAP treatment well and all AHI of them decreased significantly by CPAP (from 40 to 1.2), but two patients were not and AHI of them did not decrease. In the group with good CPAP treatment, before CPAP treatment, mean number of times to urinate at night was 4.5. And after CPAP treatment, mean number of times to urinate at night was 1.5. In the group with poor CPAP treatment, mean number of times to urinate at night was 5. And after CPAP treatment, mean number of times to urinate at night was 4.5.
Interpretation of results 
In PD patients with SA and good CPAP treatment, CPAP improved not only SA but also nocturia/night-time urinary frequency. In PD patients with SA and poor CPAP treatment, CPAP could not improve nocturia/night-time urinary frequency because SA can not be improved.
Concluding message 
CPAP has beneficial effect on nocturia/night-time urinary frequency in PD patients with SA. CPAP can become a useful alternative for nocturia/night-time urinary frequency in PD patients.
References 
  1. Wang T, Huang W, Zong H, Zhang Y. The Efficacy of Continuous Positive Airway Pressure Therapy on Nocturia in Patients With Obstructive Sleep Apnea: A Systematic Review and Meta-Analysis. Int Neurourol J 2015: 19: 178-184.
  2. Di Bello F, Napolitano L, Abate M, et al. Nocturia and obstructive sleep apnea syndrome: A systematic review. Sleep Med Rev 2023: 69: 10178.
Disclosures
Funding no funding or grant Clinical Trial No Subjects Human Ethics Committee IUHW university Helsinki Yes Informed Consent Yes AI Not at all
07/06/2026 03:53:18