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Research Type
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Pure and Applied Science / Translational |
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Keywords
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detrusor underactivity and lower urinary tract dysfunction Ageing, ischemia, free radicals and mitochondrial autophagy inflammation, fibrosis and relaxin |
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Target Audience
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Scientists, urologists and other healthcare workers interested in the diagnosis, pathophysiology and treatment of underactive bladder (UAB). |
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Aims and Objectives
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This workshop will present up to date information on the clinical description and diagnosis of UAB, associated co-morbidities, its pathophysiology and new drug targets. Topics will include: the pathological implications of aging; bladder ischemia, inflammation and fibrosis; their impact on decreased detrusor force generation and/or contractility; and the involvement of free radical formation and mitophagy. The therapeutic relevance of free-radical scavengers, as well as anti-inflammatory and antifibrotic agents will be discussed.
Learning Objectives - 1) Provide up-to-date information on the clinical implications of UAB as a cause of impaired bladder emptying in the elderly population and in young women afflicted with Fowler’s syndrome. This workshop will enhance our understanding of the basic science of ageing and will provide knowledge to develop strategies that will increase the ‘health-span’ of the ageing adult.
2) Identify comorbidities associated with UAB, discuss relevant animal models and show findings on the therapeutic benefits of free radical scavengers, anti-inflammatory and antifibrotic agents on the underactive bladder.
3) Characterise cellular pathways and mechanisms of action that may be responsible for UAB and whether they involve altered detrusor force generation and/or bladder sensation.
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