ICS 2015 Scientific Oral ePoster Session S31 - Biomarkers and Molecular Mechanisms

Speakers
	Scientific Oral ePoster Session S31
	Thursday 8th October 2015
	16:30 - 17:45
	E-Poster Area (220A)
	Lunch provided
J James Innes Gillespie ICS Chair N Naoki Yoshimura ICS Chair C Chris E Constantinou ICS Chair L Lysanne Campeau ICS Chair
Learning Objectives
To examine novel research findings in the field of Biomarkers and Molecular Mechanisms. To discuss methodological challenges for conducting research in the field of Biomarkers and Molecular Mechanisms. To discern the internal and external generalizability of these research results in order to implement changes in research methods or clinical practice within the participant's own setting.

16:30

#458 The use of biomarkers in the diagnosis and treatment of overactive bladder: Can we predict the patients who will be resistant to treatment?

Presenter: Okan Alkis

Alkis O¹, Zumrutbas A E¹, Toktas C¹, Aybek H², Aybek Z¹
1. Pamukkale University School of Medicine, Department of Urology, 2. Pamukkale University School of Medicine, Department of Biochemistry
Overactive Bladder, Biochemistry , Pharmacology, Pre-Clinical testing
ePoster Station 1

16:30

#459 Brain Derived Neurotrophic Factor (BDNF) gene expression in human bladder

Presenter: Rufus Cartwright

Bhide A¹, Cartwright R¹, Offiah I², Bray R¹, Franklin L¹, O'Reilly B³, McMahon S², Khullar V¹
1. Imperial College London, 2. King's College London, 3. University College Cork
Basic Science, Painful Bladder Syndrome/Interstitial Cystitis (IC), Overactive Bladder
ePoster Station 2

16:30

#460 Urothelial Dysfunction and Protein Expressions in Patients with Chronic Kidney Diseaseand End-Stage Renal Disease and Different Sensory Dysfunction

Presenter: Hann-Chorng Kuo

Chen S¹, Kuo H¹
1. Department of Urology, Buddhist Tzu Chi General Hospital and Tzu Chi University, Hualien, Taiwan
Detrusor Hypocontractility, Physiology, Molecular Biology
ePoster Station 3

16:30

#461 Intravesical Onabotulinumtoxin-A injections decrease both nerve growth factor and brain derived neurotrophic factor levels in bladder tissue and urine in patients with idiopathic and neurogenic detrusor overactivity

Presenter: Rizwan Hamid

Seth J¹, Burki J¹, Ochulor J¹, Hamid R²
1. National Hospital for Neurology and Neurosurgery, 2. University College Hospital NHS Trust
Detrusor Overactivity, Multiple Sclerosis, Basic Science
ePoster Station 4

16:30

#462 Urinary proteomic pattern in female stress urinary incontinence: a pilot study

Presenter: Marianne Koch

Koch M¹, Mitulovic G², Hanzal E¹, Umek W¹, Seyfert S², Mohr T³, Kölbl H¹, Laterza R M¹
1. Department of Obstetrics and Gynecology, Medical University of Vienna, 2. Core Facilities Proteomics, Clinical Institute of Laboratory Medicine, Medical University of Vienna, 3. CEO Science Consult Thomas Mohr KG
Basic Science, Female, Molecular Biology, Pathophysiology, Stress Urinary Incontinence
ePoster Station 5

16:30

#463 The Correlation Of Urine Nerve Growth Factor Levels With Bladder Nerve Staining Concentration And Symptom Score Severity In Interstitial Cystitis Patients

Presenter: Senol Tonyali

Tonyali S¹, Ates D², Akbiyik F³, Ergen A¹
1. Hacettepe University School of Medicine Department of Urology, 2. Hitit University Corum Research and Education Hospital Department of Pathology, 3. Hacettepe University School of Medicine Department of Biochemistry
Clinical Trial, Female, Painful Bladder Syndrome/Interstitial Cystitis (IC), Prospective Study, Urgency/Frequency
ePoster Station 6

16:30

#464 CHRONIC ISCHEMIA ALTERS THE BLADDER PROTEOMIC PROFILES AND ACTIVATES DEGENERATIVE PATHWAYS AND SURVIVAL SIGNALING

Presenter: Kazem Azadzoi

Su N¹, Choi H¹, Yang J¹, Azadzoi K¹
1. VA Boston Healthcare System & Boston University Medical School
Basic Science, Detrusor Overactivity, Overactive Bladder, Voiding Dysfunction , Pathophysiology
ePoster Station 7

16:30

#465 ISCHEMIA SURVIVAL SIGNALING VIA PI3-K/Akt PATHWAY MEDIATES OVERACTIVE BLADDER PROGRESSION TO UNDERACTIV BLADDER

Presenter: Kazem Azadzoi

Zhao Z¹, Yang J¹, Li Y¹, Azadzoi K¹
1. VA Boston Healthcare System & Boston University Medical School
Basic Science, Underactive Bladder, Overactive Bladder, Pathophysiology
ePoster Station 8

16:30

#466 AMP-activated Protein Kinase Suppresses Connexin43 in Bladder Smooth Muscle Cells and Ameliorates Voiding Dysfunction in Cyclophosphamide-induced Mouse Cystitis

Presenter: Xiling Zhang

Zhang X¹, Yao J², Ihara T³, Sawada N³, Mitsui T³, Takeda M³
1. Department of Molecular Signaling and Urology, University of Yamanashi, 2. Department of Molecular Signaling, University of Yamanashi, 3. Department of Urology, University of Yamanashi
Detrusor Overactivity, Voiding Dysfunction , Animal Study, Basic Science, Pathophysiology
ePoster Station 9

16:30

#467 HORMONE MODULATION OF TOLL-LIKE RECEPTOR 5 IN CULTURED HUMAN BLADDER EPITHELIAL CELLS

Presenter: Caroline Foust-Wright

Foust-Wright C¹, Pulliam S¹, Batalden R¹, Berk T¹, Weinstein M¹, Wakamatsu M¹, Phillippe M¹
1. Massachusetts General Hospital
Basic Science, Female, Cell Culture, Infection, Urinary Tract
ePoster Station 10

16:30

#468 HYPOXIA-INDUCED METABOLIC STRESS IN BLADDER UROTHELIAL AND SMOOTH MUSCLE CELLS

Presenter: Monica Velasquez Flores

Velasquez Flores M¹, Cammisotto P¹, Campeau L¹
1. Lady Davis Institute for Medical Research, McGill University, Montreal, QC Canada
Basic Science, Cell Culture, Molecular Biology, Pathophysiology
ePoster Station 11

16:30

#469 In male rats, castration led to histological changes in the bladder and blood vessels, further, the age at which castration was performed affected the degree of the histological changes.

Presenter: Tomohiro Magari

Magari T¹, Shibata Y², Arai S², Kashiwagi B², Saruki K², Suzuki K³, Suzuki K²
1. Department of Urology, Kurosawa Hospital,Takasaki,Japan, 2. Department of Urology, Gunma University Graduate School of Medicine, Maebashi, Japan, 3. Department of Pathology, Gunma University Graduate School of Health Sciences, Maebashi, Japan
Animal Study, Male, Hormone Therapy
ePoster Station 12

16:30

#470 Desensitisation of urethral smooth muscle: interaction between adrenoceptor and muscarinic receptor mediated pathways

Presenter: Oladayo Folasire

Folasire O¹, Sellers D¹, Chess-Williams R¹
1. Bond University
Female, Pharmacology, Incontinence, Stress Urinary Incontinence
ePoster Station 13

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Biomarkers and Molecular Mechanisms

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